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The dephosphorylation of CDc25C on Thr14/Tyr15 by CDc25C inhibits phosphate removal from Cdc2, thus leading to G2/M arrest when CDc2 fails to activate (77, 78) ( Figure 4B )

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Clin Endocrinol (Oxf) 44 : 501–514 Unterman TG (1993) Insulin-like growth factor binding protein-1: identification, purification, and regulation in fetal and adult life