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Peroxyl radicals (ROO•) constitute another class of oxygen-derived FRs

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ER Calcium Depletion and Unfolded Protein Response Chronic ethanol exposure also stimulates the release of calcium from the ER via inositol 1,4,5-trisphosphate receptors (IP 3 Rs) and ryanodine receptors (RyRs), leading to ER calcium depletion and the induction of ER stress