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Brown urine Medicines that turn urine brown include: antipsychotic drugs, such as chlorpromazine and thioridazine antibiotics, such as metronidazole and nitrofurantoin phenytoin, or Dilantin, an epilepsy drug sennoside laxatives, such as Senna-Lax and Senokot Deep purple urine A condition called porphyria causes urine to appear deep purple