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MDH2 gene expression was shown to increase with aging in one GABAergic neuron cluster in the hypothalamus (Jin et al., 2025), while MDH2 protein levels increased substantially from birth to 6 months of age but then dropped slightly from 6 to 12 months of age (Yang et al., 2008)

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Research on EGCG improving the degenerative changes of the brain in AD model mice induced with chemical drugs