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Semaglutide, the first dedicated GLP-1 obesity treatment, achieved 14.9% body weight reduction in the STEP 1 trial

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Its combination of receptor-independent engagement of lipid-metabolism pathways, modulation of β3-adrenergic receptor expression, and absence of growth-hormone-receptor engagement makes it a valuable investigational laboratory peptide for studying HGH-fragment pharmacology and structure–activity research models