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12 Immune Function Patients with ALF are in a state of multifactorial immunoparesis , in part due to decreased protection against gut bacteria, decreased immune complement secretion and decreased function of existing immune cells, to name a few

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One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)